Patients are demanding a longer lasting filler because of “filler fatigue.” Filler Fatigue refers to the feeling of frustration as a result of having to come back frequently in order to maintain a youthful appearance. A recent Harris Poll Survey revealed that out of the 9 million dermal filler patients in the U.S, this phenomenon is affecting 8 million patients. Many of these patients are impacted by the time, pain and cost of regular and on-going filler injections.